History of Medicine: Hemorraghic Fevers: Emerging Disease Outline

Hemorragic and Marburg Fever(outbreak centered in lab)

Lassas Fever

  • Centered in African setting, quite high fever and injection in liquid around brain. because of hemorrhaging- eventually shock, looking at who gets it vs. who dies. mortality rate. transition. can this transfer from human to human? 
  • Reported like crazy because people panicked over it- looking at the possibility of this disease.
  • Nigerian man (Ohio) goes back to Nigeria for mother and father’s funeral. came back to chicago-went to dr. for fever-flu epidemic- says you have flu- but three days later and bloody dihareeah= no flu Diagnosed to late: Lassa.
  • Hemmoragic fever #1 CDC must track everyone he come in contact with. None of them developed Lassa, mortality rate 15-20% but can reach 50%. 
  • Ebola (they love in movies) Looks scarier in a lot of ways and that kind  of drama draws media reporters. 1976- 1st outbreak: Zaire, Sudan. (news flash we are in a recession.) Zombie Apocalypse, bath salts and the Hunger Games: the demographic they want to see to. and get the copycats. on thing that works and were gonna keep doing it- the interest that pop culture seems to have.
  • anyway: EBOLA: Symptoms: Fever, joint pain, a hemmoragtic rash- see capillaries all over your body, imploding. Death- rates seem pretty high. earliest outbreaks centered around bush hospitals. Scary how quickly this spread to health care workers. Family members came in to help take care of family member and get Ebola as well. 
  • Accountable vs. Responsible
  • death toll in early outbreaks reached 90%, and 90% mortality rates scared the fucking shit out of people. 
  • Ebola will rage and fade without any obvious reasons
  • has to have some sort of reservoir (animal?) to hang out- we don’t know what that is. As of 2010, no whatever- currently a vaccine in trail. 50-80% mortality rate: much higher… thank 90?
  • C. Multi-drug resistant Tuberculosis.
  • Relatively rare by 1960s. tended to happen in poorer countries…less sanitation, not high priority, seemed slowly eradicated. Came roaring back in 1980’s and is major health problem now.
  • People with suppressed immune system- highly vulnerable to this disease. AIDS patients. drug addicts. prison patients. homeless(very high rates).
  • Outbreaks do work very differently in different places (what is available) transient-nut on the grid.
  • If they were getting treatment- a lot of people could not afford to complete treatment or just stopped. Because they felt better, and treatment was expensive. But this encouraged micro to adapt to that drug. Now several strains circulating society. 7 different tuberculosis medication. Socially vulnerable population, 6-24 months of drug therapy.
  • 1885-1991 for Africa: Tuberculosis cases rose 300% where does the right of the individual end and the right of society begin. Man and the Airplane. World has to deal with what they’ve never dealt with before- blurred lines.
  • MRSA outbreaks: Associated with high school and college locker rooms, with gyms. It begins with boil or small red “zits”. become deep painful Abbesses. 1% of population carries staph form of Bacteria- Overuse of Antibiotics- ear infection vs. Cold, encourage a situation where drug resistant bacteria can pop up.




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